Reduced fidelity of neural representation underlies episodic memory decline in normal aging

L Zheng, Z Gao, X Xiao, Z Ye, C Chen, G Xue - Cerebral Cortex, 2018 - academic.oup.com
Emerging studies have emphasized the importance of the fidelity of cortical representation in
forming enduring episodic memory. No study, however, has examined whether there are
age-related reductions in representation fidelity that can explain memory declines in normal
aging. Using functional MRI and multivariate pattern analysis, we found that older adults
showed reduced representation fidelity in the visual cortex, which accounted for their
decreased memory performance even after controlling for the contribution of reduced …
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